Lipophagy is defined as the autophagic degradation of intracellular lipid droplets (LDs).
While the field of lipophagy research is relatively young, an expansion of research in this …

Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of
cellular processes, including responses to nutrient availability and composition, stress …

Lipid droplets (LD) have long been considered as mere fat drops; however, LD have lately
been revealed to be ubiquitous, dynamic and to be present in diverse organelles in which …

This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well
as how these pathway ys communicate, how they affect lipid metabolism and energy …

Transforming growth factor β1 (TGF‑β1) is one of the most important fibrogenic factors
promoting the activation of hepatic stellate cells (HSCs). Autophagy is a process used by …

Activation of hepatic stellate cells (HSCs) is a pivotal event in liver fibrosis, characterized by
dramatic disappearance of lipid droplets (LDs). Although LD disappearance has long been …

Alcohol-related liver disease (ALD) and drug-induced liver injury (DILI) are common causes
of severe liver disease, and successful treatments are lacking. Autophagy plays a protective …

Autophagy is a “self-eating” process that engulfs cellular contents for their subsequent
digestion in lysosomes to engage the metabolic need in response to starvation or …

Alcohol consumption is a well‐established risk factor for the onset and progression of fatty
liver disease. An estimated 90% of heavy drinkers are thought to develop significant liver …

Autophagy-mediated lipotoxicity plays a critical role in the progression of diabetic
nephropathy (DN), but the precise mechanism is not fully understood. Whether lipophagy, a …