The stiffness of living tissues and its implications for tissue engineering

CF Guimarães, L Gasperini, AP Marques… - Nature Reviews …, 2020 - nature.com
The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …

Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease

P Lacolley, V Regnault, P Segers… - Physiological …, 2017 - journals.physiology.org
The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Mechanoreciprocity in cell migration

S Van Helvert, C Storm, P Friedl - Nature cell biology, 2018 - nature.com
Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

S Musah, A Mammoto, TC Ferrante… - Nature biomedical …, 2017 - nature.com
An in vitro model of the human kidney glomerulus—the major site of blood filtration—could
facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a …

Are cancer cells really softer than normal cells?

C Alibert, B Goud, JB Manneville - Biology of the Cell, 2017 - Wiley Online Library
Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …

Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility

G Fiorentino, D Cimadomo, F Innocenti… - Human …, 2023 - academic.oup.com
BACKGROUND Folliculogenesis occurs in the highly dynamic environment of the ovary.
Follicle cyclic recruitment, neo-angiogenesis, spatial displacement, follicle atresia and …

Spaceflight-induced intracranial hypertension and visual impairment: pathophysiology and countermeasures

LF Zhang, AR Hargens - Physiological reviews, 2018 - journals.physiology.org
Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained
major risk for future long-duration spaceflight. NASA recently redefined this syndrome as …

Mechanical regulation of gene expression in cardiac myocytes and fibroblasts

JJ Saucerman, PM Tan, KS Buchholz… - Nature Reviews …, 2019 - nature.com
The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Skeletal changes during and after spaceflight

L Vico, A Hargens - Nature Reviews Rheumatology, 2018 - nature.com
Abstract Space sojourns are challenging for life. The ability of the human body to adapt to
these extreme conditions has been noted since the beginning of human space travel …

From mechanical resilience to active material properties in biopolymer networks

F Burla, Y Mulla, BE Vos, A Aufderhorst-Roberts… - Nature Reviews …, 2019 - nature.com
The cells and tissues that make up our body manage contradictory mechanical demands. It
is crucial for their survival to be able to withstand large mechanical loads, but it is equally …