Alkaloids are important chemical compounds that serve as a rich source for drug discovery.
Numerous alkaloids screened from medicinal plants and herbs showed antiproliferative and …

Rutaecarpine is a bioactive alkaloid isolated from Evodia rutaecarpa (Wu Zhu Yu, Family:
Rutaceae), a versatile medicinal herb which is clinically used to treat headache, abdominal …

An atom and step economy cascade trifluoromethylation/cyclization of unactivated alkene
with Langlois reagent as a CF3 source is described. A variety of polycyclic quinazolinones …

Breast cancer is one of the major causes of mortality in women worldwide. The current
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …

The enzyme butyrylcholinesterase (BChE) and the human cannabinoid receptor 2 (h CB2R)
represent promising targets for pharmacotherapy in the later stages of Alzheimer's disease …

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization
reaction between commercially available anthranils and cyclic amines is described. The …

Rutaecarpine (RUT) is a natural pentacyclic indolopyridoquinazolinone alkaloid first isolated
from one of the most famous traditional Chinese herbs, Evodia rutaecarpa, which is used for …

A direct decarboxylative cyclization between readily available isatoic anhydrides and cyclic
amines was established to construct polycyclic fused quinazolinones employing …

The novel organic–inorganic nanohybrid superparamagnetic (γ-Fe2O3@ CPTMS–
guanidine@ SO3H) nanocatalyst modified with sulfonic acid represents an efficient and …

Natural products are a rich resource in drug discovery. In the report, series novel
rutaecarpine-derived compounds with potent anti-inflammatory activity and therapeutic …