The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

Progressive supranuclear palsy (PSP), previously believed to be a common cause of
atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

In eukaryotic cells, the endoplasmic reticulum (ER) is the cell compartment involved in
secretory protein translocation and quality control of secretory protein folding. Different …

The proposed molecular mechanisms underlying neurodegenerative pathogenesis are
varied, precluding the development of effective therapies for these increasingly prevalent …

The RNA‐like endoplasmic reticulum kinase (PERK) is genetically associated with the
tauopathy progressive supranuclear palsy (PSP). To elucidate the functional mechanisms …

Progressive supranuclear palsy (PSP) is an atypical parkinsonism with prominent 4R-tau
neuropathology, and the classical clinical phenotype is characterized by vertical …

One of the pathways of the unfolded protein response, initiated by PKR-like endoplasmic
reticulum kinase (PERK), is key to neuronal homeostasis in neurodegenerative diseases …

A key site of translation control is the phosphorylation of the eukaryotic translation initiation
factor 2α (eIF2α), which reduces the rate of GDP to GTP exchange by eIF2B, leading to …