Endolysin, a promising solution against antimicrobial resistance

M Rahman, W Wang, Q Sun, JA Shah, C Li, Y Sun, Y Li… - Antibiotics, 2021 - mdpi.com
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the
effective prevention and control of ever-increasing infectious diseases. The advent of …

Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application

KM Danis-Wlodarczyk, DJ Wozniak, ST Abedon - Antibiotics, 2021 - mdpi.com
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

Bacteriophage endolysins: applications for food safety

M Schmelcher, MJ Loessner - Current opinion in biotechnology, 2016 - Elsevier
Highlights•Endolysins are promising agents for detection and control of foodborne
pathogens.•Cell wall binding domains can be used for specific detection of bacteria in …

Effective removal of staphylococcal biofilms on various food contact surfaces by Staphylococcus aureus phage endolysin LysCSA13

Y Cha, B Son, S Ryu - Food microbiology, 2019 - Elsevier
Staphylococcal biofilms are recognized as a significant problem in the food industry
because of their high resistance to antibiotics, and the use of bacteriophages or endolysins …

Metagenome data on intestinal phage-bacteria associations aids the development of phage therapy against pathobionts

K Fujimoto, Y Kimura, M Shimohigoshi, T Satoh… - Cell host & …, 2020 - cell.com
The application of bacteriophages (phages) is proposed as a highly specific therapy for
intestinal pathobiont elimination. However, the infectious associations between phages and …

Phage Endolysin LysP108 Showed Promising Antibacterial Potential Against Methicillin-resistant Staphylococcus aureus

Y Lu, Y Wang, J Wang, Y Zhao, Q Zhong… - Frontiers in cellular …, 2021 - frontiersin.org
As a potential antibacterial agent, endolysin can directly lyse Gram-positive bacteria from the
outside and does not lead to drug resistance. Considering that XN108 is the first reported …

Potential of bacteriophage proteins as recognition molecules for pathogen detection

SP Costa, CL Nogueira, AP Cunha… - Critical Reviews in …, 2023 - Taylor & Francis
Bacterial pathogens are leading causes of infections with high mortality worldwide having a
great impact on healthcare systems and the food industry. Gold standard methods for …

Catalytic diversity and cell wall binding repeats in the phage‐encoded endolysins

SS Broendum, AM Buckle… - Molecular …, 2018 - Wiley Online Library
Bacteriophage‐encoded endolysins can recognize and bind specific bacteria, and act to
cleave the glycosidic and/or amide bonds in the peptidoglycan (PG) bacterial cell wall …

Preparation and characterization of endolysin-containing liposomes and evaluation of their antimicrobial activities against gram-negative bacteria

J Bai, E Yang, PS Chang, S Ryu - Enzyme and microbial technology, 2019 - Elsevier
The overuse and misuse of antibiotics in treating bacterial infections cause the rapid
emergence of drug-resistant bacteria, suggesting that the development of alternative …

Characterization of a novel endolysin LysSA11 and its utility as a potent biocontrol agent against Staphylococcus aureus on food and utensils

Y Chang, M Kim, S Ryu - Food Microbiology, 2017 - Elsevier
Here we show that the LysSA11 endolysin, derived from the virulent Staphylococcus aureus
phage SA11, has lytic activity against staphylococcal strains. Bioinformatics analysis …