Harnessing multimodal data integration to advance precision oncology
Advances in quantitative biomarker development have accelerated new forms of data-driven
insights for patients with cancer. However, most approaches are limited to a single mode of …
insights for patients with cancer. However, most approaches are limited to a single mode of …
Brain cell type-specific cholesterol metabolism and implications for learning and memory
Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol
H Wang, JA Kulas, C Wang… - Proceedings of the …, 2021 - National Acad Sciences
Alzheimer's disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau
tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol …
tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol …
Ligand binding at the protein–lipid interface: strategic considerations for drug design
J Payandeh, M Volgraf - Nature Reviews Drug Discovery, 2021 - nature.com
Many drug targets are embedded within the phospholipid bilayer of cellular membranes,
including G protein-coupled receptors, ion channels, transporters and membrane-bound …
including G protein-coupled receptors, ion channels, transporters and membrane-bound …
The role of high cholesterol in age-related COVID19 lethality
Coronavirus disease 2019 (COVID19) is a respiratory infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …
Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex
Cortical circuits are composed predominantly of pyramidal-to-pyramidal neuron
connections, yet their assembly during embryonic development is not well understood. We …
connections, yet their assembly during embryonic development is not well understood. We …
Vitamin D and Covid-19: an update on evidence and potential therapeutic implications
The world is now experiencing its third major epidemic of coronavirus (CoV) infections
began in Wuhan, Hubei, China, in late 2019 and named COVID-19. After an initial explosive …
began in Wuhan, Hubei, China, in late 2019 and named COVID-19. After an initial explosive …
The shared role of cholesterol in neuronal and peripheral inflammation
Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture
Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a
treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro …
treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro …
Role of lipid rafts in pathogen-host interaction-a mini review
R Kulkarni, EAC Wiemer, W Chang - Frontiers in Immunology, 2022 - frontiersin.org
Lipid rafts, also known as microdomains, are important components of cell membranes and
are enriched in cholesterol, glycophospholipids and receptors. They are involved in various …
are enriched in cholesterol, glycophospholipids and receptors. They are involved in various …