The paradigm that chronic rejection causes all progressive late allograft failure has been
replaced by a hypothesis of cumulative damage, where a series of time-dependent immune …

The discovery that cyclosporine A (CsA) was a powerful immunosuppressant had a
significant impact on transplant medicine. Its molecular mechanism of action has been well …

Pathology consensus review for clinical trials and disease classification has historically
been performed by manual light microscopy with sequential section review by study …

Background: Immunosuppressant therapy is essential in the prevention of organ transplant
rejection. Objective: To evaluate the long-term neurodevelopmental outcomes of children …

Cardiovascular events are one of the leading causes of mortality in kidney transplant
recipients. Hypertension is the most common comorbidity accompanying chronic kidney …

Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell
cultures. Background Nephrotoxicity, accelerated atherosclerosis, and graft vascular …

Hypertension is common among kidney transplant recipients and may result from traditional
risk factors or transplant specific variables, which commonly include donor associated …

Background. Glomerulosclerosis (GS) is characteristic of chronic allograft nephropathy and
graft failure; however, its natural history and pathophysiology are poorly defined. Methods …

Patient 1. A 58-year-old man was hospitalized with hypertension, 168/114 mm Hg,
congestive heart failure secondary to fluid retention, and a serum creatinine of 6.9 mgldl. Six …

Abstract Background. Chronic cyclosporine A (CsA) nephropathy is a well described side
effect of CsA treatment. CsA has been shown to induce the synthesis of extracellular matrix …