Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
SARS-CoV-2 non-structural proteins and their roles in host immune evasion
Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …
continues to threaten public health. The etiological agent of this devastating pandemic …
Coronaviral RNA-methyltransferases: function, structure and inhibition
R Nencka, J Silhan, M Klima, T Otava… - Nucleic acids …, 2022 - academic.oup.com
Abstract Coronaviral methyltransferases (MTases), nsp10/16 and nsp14, catalyze the last
two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for …
two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for …
Nsp16 shields SARS–CoV‐2 from efficient MDA5 sensing and IFIT1‐mediated restriction
A Russ, S Wittmann, Y Tsukamoto, A Herrmann… - EMBO …, 2022 - embopress.org
Methylation of the mRNA 5′ cap by cellular methyltransferases enables efficient translation
and avoids recognition by innate immune factors. Coronaviruses encode viral 2′‐O …
and avoids recognition by innate immune factors. Coronaviruses encode viral 2′‐O …
BA. 1, BA. 2 and BA. 2.75 variants show comparable replication kinetics, reduced impact on epithelial barrier and elicit cross-neutralizing antibodies
The Omicron variant of SARS-CoV-2 is capable of infecting unvaccinated, vaccinated and
previously-infected individuals due to its ability to evade neutralization by antibodies. With …
previously-infected individuals due to its ability to evade neutralization by antibodies. With …
Regulation of antiviral innate immunity by chemical modification of viral RNA
N Li, TM Rana - Wiley Interdisciplinary Reviews: RNA, 2022 - Wiley Online Library
More than 100 chemical modifications of RNA, termed the epitranscriptome, have been
described, most of which occur in prokaryotic and eukaryotic ribosomal, transfer, and …
described, most of which occur in prokaryotic and eukaryotic ribosomal, transfer, and …
Metal-based strategies for the fight against COVID-19
The emerging COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has claimed over six million lives globally to date. Despite the …
coronavirus 2 (SARS-CoV-2) has claimed over six million lives globally to date. Despite the …
The nsp15 nuclease as a good target to combat SARS-CoV-2: mechanism of action and its inactivation with FDA-approved drugs
M Saramago, VG Costa, CS Souza, C Bárria… - Microorganisms, 2022 - mdpi.com
The pandemic caused by SARS-CoV-2 is not over yet, despite all the efforts from the
scientific community. Vaccination is a crucial weapon to fight this virus; however, we still …
scientific community. Vaccination is a crucial weapon to fight this virus; however, we still …
5′-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2′-O-methyltransferases
R Ahmed-Belkacem, P Sutto-Ortiz, A Delpal… - Bioorganic …, 2024 - Elsevier
Abstract Viral RNA cap 2′-O-methyltransferases are considered promising therapeutic
targets for antiviral treatments, as they play a key role in the formation of viral RNA cap-1 …
targets for antiviral treatments, as they play a key role in the formation of viral RNA cap-1 …
The basis and promise of programmable RNA editing and modification
One key advantage of RNA over genomic editing is its temporary effects. Aside from current
use of DNA-targeting CRISPR-Cas9, the more recently discovered CRISPR-Cas13 has …
use of DNA-targeting CRISPR-Cas9, the more recently discovered CRISPR-Cas13 has …