Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …

Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) is a master regulator
of mitochondrial biogenesis. Reduced PGC-1α abundance is linked to skeletal muscle …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

This study was conducted to characterize metabolic features of the breast muscle (pectoralis
major) in chickens affected with the Wooden Breast myopathy. Live birds from two purebred …

Glucose/glycogen metabolism is a primary metabolic pathway acting on a variety of cellular
needs, such as proliferation, growth, and survival against stresses. The multiple regulatory …

Elevated levels of tumor necrosis factor (TNFα) are implicated in the development of insulin
resistance, but the mechanisms mediating these chronic effects are not completely …

Exercise training is commonly prescribed for treatment of nonalcoholic fatty liver disease
(NAFLD). We sought to determine whether exercise training prevents the development of …

AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that is expressed in most
mammalian tissues including cardiac muscle. Among the multiple biological processes …

Background—Mutations in the γ2 subunit (PRKAG2) of AMP-activated protein kinase
produce an unusual human cardiomyopathy characterized by ventricular hypertrophy and …