Non-invasive transcranial ultrasound stimulation for neuromodulation

G Darmani, TO Bergmann, KB Pauly, CF Caskey… - Clinical …, 2022 - Elsevier
Transcranial ultrasound stimulation (TUS) holds great potential as a tool to alter neural
circuits non-invasively in both animals and humans. In contrast to established non-invasive …

[HTML][HTML] Ultrasound neuromodulation: a review of results, mechanisms and safety

J Blackmore, S Shrivastava, J Sallet, CR Butler… - Ultrasound in medicine …, 2019 - Elsevier
Ultrasonic neuromodulation is a rapidly growing field, in which low-intensity ultrasound (US)
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …

Ultrasonic neuromodulation causes widespread cortical activation via an indirect auditory mechanism

T Sato, MG Shapiro, DY Tsao - Neuron, 2018 - cell.com
Ultrasound has received widespread attention as an emerging technology for targeted, non-
invasive neuromodulation based on its ability to evoke electrophysiological and motor …

Ultrasonic neuromodulation via astrocytic TRPA1

SJ Oh, JM Lee, HB Kim, J Lee, S Han, JY Bae… - Current Biology, 2019 - cell.com
Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain
stimulation technology for treating various neurological and psychiatric disorders. However …

Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane

B Sorum, RA Rietmeijer… - Proceedings of the …, 2021 - National Acad Sciences
Ultrasound modulates the electrical activity of excitable cells and offers advantages over
other neuromodulatory techniques; for example, it can be noninvasively transmitted through …

Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior

A Fomenko, KHS Chen, JF Nankoo, J Saravanamuttu… - Elife, 2020 - elifesciences.org
Low-intensity transcranial ultrasound (TUS) can non-invasively modulate human neural
activity. We investigated how different fundamental sonication parameters influence the …

Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology

KR Murphy, JS Farrell, J Bendig, A Mitra, C Luff… - Neuron, 2024 - cell.com
Focused ultrasound can non-invasively modulate neural activity, but whether effective
stimulation parameters generalize across brain regions and cell types remains unknown …

Neuromodulation with transcranial focused ultrasound

J Kubanek - Neurosurgical focus, 2018 - thejns.org
The understanding of brain function and the capacity to treat neurological and psychiatric
disorders rest on the ability to intervene in neuronal activity in specific brain circuits. Current …

A clinical system for non-invasive blood–brain barrier opening using a neuronavigation-guided single-element focused ultrasound transducer

AN Pouliopoulos, SY Wu, MT Burgess… - Ultrasound in medicine …, 2020 - Elsevier
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is currently being
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …

Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates

AN Pouliopoulos, N Kwon, G Jensen, A Meaney… - Scientific reports, 2021 - nature.com
An emerging approach with potential in improving the treatment of neurodegenerative
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …