[HTML][HTML] The insecticide deltamethrin enhances sodium channel slow inactivation of human Nav1. 9, Nav1. 8 and Nav1. 7

SN Bothe, A Lampert - Toxicology and applied pharmacology, 2021 - Elsevier
The insecticide deltamethrin of the pyrethroid class mainly targets voltage-gated sodium
channels (Navs). Deltamethrin prolongs the opening of Navs by slowing down fast …

Intrinsic mechanisms in the gating of resurgent Na+ currents

JL Ransdell, JD Moreno, D Bhagavan, JR Silva… - Elife, 2022 - elifesciences.org
The resurgent component of the voltage-gated sodium current (I NaR) is a depolarizing
conductance, revealed on membrane hyperpolarizations following brief depolarizing voltage …

[PDF][PDF] Susceptibility of the human NaV1. 7 voltage-gated sodium channel to pyrethroid insecticides

S Sharifnia - 2024 - eprints.nottingham.ac.uk
Pyrethroid insecticides, generally regarded as low risk for human and mammalian toxicity,
have paradoxically been associated with neurological symptoms among agricultural …

Implementation of a high throughput screening assay to identify and characterize insecticides acting on ion channels

A Brockmann - 2023 - bonndoc.ulb.uni-bonn.de
With 800 million people suffering from hunger, new innovative crop protection products are
required to ensure food supply and stop hunger. The voltage-sensitive sodium channel …

[PDF][PDF] Pharmacological modification of sodium channel Nav1. 9 activity

S Steup - 2022 - publications.rwth-aachen.de
Voltage-gated sodium channels (Navs) generate the sodium current that is responsible for
the rapid upstroke of the action potential. Therefore, they are a very important component of …

Investigação do Efeito Antiarrítmico do Eugenol em modelo de arritmia induzida por corrente de sódio tardia

PIC Nunes - 2021 - saberaberto.homologacao.uneb.br
As arritmias são a principal causa de morte súbita cardíaca em pacientes com disfunções
no coração sendo, portanto, um importante problema epidemiológico e de saúde pública. O …