To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

The WNT/β-catenin signaling pathway is a highly conserved and tightly controlled molecular
mechanism that regulates embryonic development, cellular proliferation and differentiation …

Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and a leading
cause of cancer-related deaths worldwide. Ninety percent of HCC cases arise from cirrhosis …

Somatic mutations in p53, which inactivate the tumour-suppressor function of p53 and often
confer oncogenic gain-of-function properties, are very common in cancer,. Here we studied …

Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …

Multiple studies suggested using different miRNAs as biomarkers for prognosis of
hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression database …

Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key
cellular functions including proliferation, differentiation, migration, genetic stability …

Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is a leading
cause of cancer-related death worldwide. It is highly refractory to most systemic therapies …

Hepatocellular carcinoma (HCC) is a disease with unique management complexity because
it displays high heterogeneity of molecular phenotypes. We herein aimed to characterize the …