Histone lysine methylation is a post-translational modification that plays a key role in the
epigenetic regulation of a broad spectrum of biological processes. Moreover, the …

Given that obesity and diabetes have been major public health concerns and that disease
morbidities have been rising continuously, effective treatment for these diseases is urgently …

Abstract Background RNA N6-Methyladenosine (m6A) modification is implicated in the
progression of human cancers including cholangiocarcinoma (CCA). METTL16 is recently …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Abstract C2H2 zinc-finger (ZF) proteins form the largest family of DNA-binding transcription
factors coded by mammalian genomes. In a typical DNA-binding ZF module, there are …

Background Colorectal cancer (CRC) is the third most deadly and fourth most diagnosed
cancer worldwide. Despite the progress in early diagnosis and advanced therapeutic …

Abstract Birt–Hogg–Dubé syndrome (BHD) is an autosomal dominant disorder
characterized by fibrofolliculomas, pulmonary cysts, pneumothoraces and renal cell …

PRDM12 is a member of the PRDI-BF1 (positive regulatory domain I-binding factor 1)
homologous domain (PRDM)-containing protein family, a subfamily of Kruppel-like zinc …

Over the past few decades, epigenetic regulators have emerged as major players in cellular
processes that drive cancer initiation and progression, and subsequently modulate the …

Based upon our demonstration that the smooth muscle cell–selective (SMC-selective)
putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A …