Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction
Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
In silico studies targeting G-protein coupled receptors for drug research against Parkinson's disease
Parkinson's Disease (PD) is a long-term neurodegenerative brain disorder that mainly
affects the motor system. The causes are still unknown, and even though currently there is …
affects the motor system. The causes are still unknown, and even though currently there is …
Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5, 5-diphenylimidazolidine-2, 4-dione scaffold: molecular docking …
The design, synthesis and pharmacological activities of a group of 5, 5-
diphenylimidazolidine-2, 4-dione bearing anilide, phenacyl and benzylidene fragments 2 …
diphenylimidazolidine-2, 4-dione bearing anilide, phenacyl and benzylidene fragments 2 …
Current research on antiepileptic compounds
CX Wei, M Bian, GH Gong - Molecules, 2015 - mdpi.com
Epilepsy affects about 1% of the world's population. Due to the fact all antiepileptic drugs
(AEDs) have some undesirable side effects and about 30% of epileptic patients are not …
(AEDs) have some undesirable side effects and about 30% of epileptic patients are not …
The role of oxazolidine derivatives in the treatment of infectious and chronic diseases
JF Branco-Junior, D RC Teixeira… - Current Bioactive …, 2017 - ingentaconnect.com
Background: Despite being known for their antibacterial activity, the oxazolidines are
molecules with wide pharmacological action and may act as anticonvulsants, anti …
molecules with wide pharmacological action and may act as anticonvulsants, anti …
Structure-property relationship of 3-(4-substituted benzyl)-1, 3-diazaspiro [4.4] nonane-2, 4-diones as new potentional anticonvulsant agents. An experimental and …
AM Lazić, BĐ Božić, VD Vitnik, ŽJ Vitnik… - Journal of Molecular …, 2017 - Elsevier
The structure-property relationship of newly synthesized 3-(4-substituted benzyl)-1, 3-
diazaspiro [4.4] nonane-2, 4-diones was studied by experimental and calculated methods …
diazaspiro [4.4] nonane-2, 4-diones was studied by experimental and calculated methods …
Synthesis and pharmacological evaluation of some N3-aryl/heteroaryl-substituted 2-(2-chlorostyryl)-6,7-dimethoxy-quinazolin-4(3H)-ones as potential anticonvulsant …
N Das, D Garabadu, AG Banerjee… - Medicinal Chemistry …, 2014 - Springer
Abstract Certain novel 3-aryl/heteroaryl-substituted 2-(2-chlorostyryl)-6, 7-dimethoxy-
quinazolin-4 (3 H)-one (5a–5l) derivatives have been synthesized and evaluated for their …
quinazolin-4 (3 H)-one (5a–5l) derivatives have been synthesized and evaluated for their …
Computer-aided drug design approaches to study key therapeutic targets in Alzheimer's disease
Alzheimer's Disease (AD) is one of the most common and complex age-related
neurodegenerative disorders in elderly people. Currently there is no cure for AD, and …
neurodegenerative disorders in elderly people. Currently there is no cure for AD, and …
Synthesis, crystal structure, spectroscopic and thermal properties of a novel complex of hydantoin-5-acetic acid with Co (II)
The complex, tetraaqua bis (hydantoin-5-acetato) cobalt (II) was synthesized by the reaction
of hydantoin-5-acetic acid and CoCl 2· 6H 2 O presence of NaHCO 3. The structure of the …
of hydantoin-5-acetic acid and CoCl 2· 6H 2 O presence of NaHCO 3. The structure of the …
Exploring Human 5HT1A/2A Receptor Through Homology Modeling and Flexible Docking Studies for the Binding Hotspot of Substituted 2,4-imidazolidinedione and …
Introduction To obtain the binding site of a model of the human 5-HT1A/2A receptor, a series
of substituted 2, 4-imidazolidinediones and oxazolidinediones were subjected to flexible …
of substituted 2, 4-imidazolidinediones and oxazolidinediones were subjected to flexible …