[HTML][HTML] Albendazole and mebendazole as anti-parasitic and anti-cancer agents: an update

JY Chai, BK Jung, SJ Hong - The Korean Journal of Parasitology, 2021 - ncbi.nlm.nih.gov
The use of albendazole and mebendazole, ie, benzimidazole broad-spectrum anthelmintics,
in treatment of parasitic infections, as well as cancers, is briefly reviewed. These drugs are …

Soil-transmitted helminth infections

PM Jourdan, PHL Lamberton, A Fenwick, DG Addiss - The lancet, 2018 - thelancet.com
More than a quarter of the world's population is at risk of infection with the soil-transmitted
helminths Ascaris lumbricoides, hookworm (Ancylostoma duodenale and Necator …

[HTML][HTML] Microtubule targeting agents in disease: classic drugs, novel roles

L Wordeman, JJ Vicente - Cancers, 2021 - mdpi.com
Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

[HTML][HTML] The antitumor potentials of benzimidazole anthelmintics as repurposing drugs

DS Son, ES Lee, SE Adunyah - Immune network, 2020 - ncbi.nlm.nih.gov
The development of refractory tumor cells limits therapeutic efficacy in cancer by activating
mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival …

[HTML][HTML] Emerging perspectives on the antiparasitic mebendazole as a repurposed drug for the treatment of brain cancers

D Meco, G Attinà, S Mastrangelo, P Navarra… - International Journal of …, 2023 - mdpi.com
Repurposing approved non-antitumor drugs is a promising and affordable strategy in drug
discovery to identify new therapeutic uses different from the original medical indication that …

[HTML][HTML] Paediatric schistosomiasis: What we know and what we need to know

DNM Osakunor, MEJ Woolhouse… - PLoS neglected tropical …, 2018 - journals.plos.org
Schistosomiasis affects over 200 million people worldwide, most of whom are children.
Research and control strategies directed at preschool-aged children (PSAC), ie,≤ 5 years …

Hepatic alveolar echinococcosis

S Bresson-Hadni, L Spahr… - Seminars in liver …, 2021 - thieme-connect.com
Hepatic alveolar echinococcosis (HAE) is a rare but severe zoonosis caused by the
pseudotumoral intrahepatic development of the larval stage of the tapeworm Echinococcus …

Hepatitis B vaccine nonresponders: Possible mechanisms and solutions

TV Saco, AT Strauss, DK Ledford - Annals of Allergy, Asthma & Immunology, 2018 - Elsevier
Abstract Objective Hepatitis B (HBV) is a viral illness that chronically infects 240 million
people worldwide, leads to liver disease, and increases risk of hepatocellular carcinoma …

Exploration of Remarkably Potential Multitarget-Directed N-Alkylated-2-(substituted phenyl)-1H-benzimidazole Derivatives as Antiproliferative, Antifungal, and …

NKN Phan, TKC Huynh, HP Nguyen, QT Le… - ACS …, 2023 - ACS Publications
Improving lipophilicity for drugs to penetrate the lipid membrane and decreasing bacterial
and fungal coinfections for patients with cancer pose challenges in the drug development …

[HTML][HTML] Advances in the pharmacological treatment of hepatic alveolar echinococcosis: From laboratory to clinic

X Xu, X Qian, C Gao, Y Pang, H Zhou, L Zhu… - Frontiers in …, 2022 - frontiersin.org
Hepatic alveolar echinococcosis (HAE) is a zoonotic parasitic disease caused by the larvae
of Echinococcus multilocularis. Because of its characteristics of diffuse infiltration and growth …