Alcohol use disorder (AUD) continues to be challenging to treat despite the best available
interventions, with two-thirds of individuals going on to relapse by 1 year after treatment …

Human neuroimaging has demonstrated the existence of large-scale functional networks in
the cerebral cortex consisting of topographically distant brain regions with functionally …

Alcohol intake leading to blood ethanol concentrations (BEC)≥ legal intoxication modifies
brain blood flow with increases in some regions and decreases in others. Brain regions …

Background Although a large percentage of chronic pain patients consume alcohol to
manage their pain, there is a significant gap in knowledge regarding the mechanisms …

In preclinical models of alcohol use disorder, the corticotropin-releasing factor (CRF)
receptor is upregulated, particularly in the extended amygdala. This upregulation is thought …

We reviewed 33 original research studies assessing brain perfusion, using consensus
guidelines from a “white paper” issued by the International Society for Magnetic Resonance …

Alcohol use disorder (AUD) has been associated with changes in the processing of internal
body signals, known as interoception. Changes in brain structure, particularly in the insula …

Identification of biomarkers for the early stages of Alzheimer's disease (AD) is an imperative
step in developing effective treatments. Cerebral blood flow (CBF) is a potential early …

The persistence of addictive behaviours despite their adverse consequences highlights
decreased punishment sensitivity as a facet of decision-making impairments in Alcohol Use …

Despite the significant amount of people who may be taking pregnenolone supplements
while drinking alcohol (ethanol), the widely documented cerebrovascular actions of …