Structure and dynamics of core/periphery networks
Recent studies uncovered important core/periphery network structures characterizing
complex sets of cooperative and competitive interactions between network nodes, be they …
complex sets of cooperative and competitive interactions between network nodes, be they …
Human diseases through the lens of network biology
LI Furlong - Trends in genetics, 2013 - cell.com
One of the challenges raised by next generation sequencing (NGS) is the identification of
clinically relevant mutations among all the genetic variation found in an individual. Network …
clinically relevant mutations among all the genetic variation found in an individual. Network …
Multifunctional proteins revealed by overlapping clustering in protein interaction network
E Becker, B Robisson, CE Chapple, A Guénoche… - …, 2012 - academic.oup.com
Motivation: Multifunctional proteins perform several functions. They are expected to interact
specifically with distinct sets of partners, simultaneously or not, depending on the function …
specifically with distinct sets of partners, simultaneously or not, depending on the function …
Human protein interaction networks across tissues and diseases
E Yeger-Lotem, R Sharan - Frontiers in genetics, 2015 - frontiersin.org
Protein interaction networks are an important framework for studying protein function,
cellular processes, and genotype-to-phenotype relationships. While our view of the human …
cellular processes, and genotype-to-phenotype relationships. While our view of the human …
Scope and limitations of yeast as a model organism for studying human tissue-specific pathways
S Mohammadi, B Saberidokht, S Subramaniam… - BMC systems …, 2015 - Springer
Background Budding yeast, S. cerevisiae, has been used extensively as a model organism
for studying cellular processes in evolutionarily distant species, including humans. However …
for studying cellular processes in evolutionarily distant species, including humans. However …
hERG channel function: beyond long QT
JJ Babcock, M Li - Acta Pharmacologica Sinica, 2013 - nature.com
To date, research on the human ether-a-go-go related gene (hERG) has focused on this
potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS) …
potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS) …
The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
Background The gastrointestinal peptide hormones cholecystokinin and gastrin exert their
biological functions via cholecystokinin receptors CCK1R and CCK2R respectively. Gastrin …
biological functions via cholecystokinin receptors CCK1R and CCK2R respectively. Gastrin …
The tumor microenvironment: focus on extracellular matrix
The extracellular matrix (ECM) regulates the development and maintains tissue
homeostasis. The ECM is composed of a complex network of molecules presenting distinct …
homeostasis. The ECM is composed of a complex network of molecules presenting distinct …
Dissecting the human protein-protein interaction network via phylogenetic decomposition
The protein-protein interaction (PPI) network offers a conceptual framework for better
understanding the functional organization of the proteome. However, the intricacy of network …
understanding the functional organization of the proteome. However, the intricacy of network …
Global versus local hubs in human protein–protein interaction network
M Kiran, HA Nagarajaram - Journal of Proteome Research, 2013 - ACS Publications
In this study, we have constructed tissue-specific protein–protein interaction networks for 70
human tissues and have identified three types of hubs based on their expression …
human tissues and have identified three types of hubs based on their expression …