The nucleic acid topoisomerases (TOP) are an evolutionary conserved mechanism to solve
topological problems within DNA and RNA that have been historically well-established as a …

Nitrofurantoin has shown exceptional durability against resistance over 70 years of use. This
longevity stems from factors such as rapid achievement of therapeutic concentrations …

Background. Escherichia coli is the most common cause of urinary tract infections and has
fluoroquinolone (FQ)-resistant strains, which are a worldwide concern. Objectives. To …

Urinary Tract Infections (UTIs) represent a common finding among females and an important
basis for antibiotic treatment. Considering the significant increase in antibiotic resistance …

Urinary tract infections (UTIs) are prevalent and recurrent bacterial infections that affect
individuals worldwide, posing a significant burden on healthcare systems. The present study …

Introduction Urinary tract infections (UTI), among which the main etiological factor is
uropathogenic Escherichia coli (UPEC, E. coli), remain an important issue for clinicians. The …

Antimicrobial resistance (AMR) has emerged as a significant global healthcare problem.
Antibiotic use has accelerated the physiologic process of AMR, particularly in Gram-negative …

We evaluated the in vitro activity of ceftibuten-avibactam against Enterobacterales causing
urinary tract infection (UTI). A total of 3216 isolates (1/patient) were consecutively collected …

Streptococcus pneumoniae is a major human pathogen of global health concern and the
rapid emergence of antibiotic resistance poses a serious public health problem worldwide …

Introduction This study explored the causal connections between gut microbiota (GM),
urinary tract infection (UTI), and potential metabolite mediators using Mendelian …