Linkers or spacers are short amino acid sequences created in nature to separate multiple
domains in a single protein. Most of them are rigid and function to prohibit unwanted …

Inheritance and maintenance of the DNA sequence and its organization into chromatin are
central for eukaryotic life. To orchestrate DNA-replication and-repair processes in the context …

Abstract α-synuclein is a neuronal protein implicated genetically in Parkinson's disease. α-
synuclein localizes to the nucleus and presynaptic nerve terminals. Here we show that α …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

The functional organization of eukaryotic DNA into chromatin uses histones as components
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …

DNA replication in eukaryotes requires nucleosome disruption ahead of the replication fork
and reassembly behind. An unresolved issue concerns how histone dynamics are …

Senescence is characterized by an irreversible cell proliferation arrest. Specialized domains
of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF) …

Summary Anti-silencing function 1 (Asf1) is a highly conserved chaperone of histones H3/H4
that assembles or disassembles chromatin during transcription, replication, and repair. The …

The genus Trichoderma contains fungi with high relevance for humans, with applications in
enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a …

Resistance to infection and clearance of cell debris in mammals depend on the activation of
the complement system, which is an important component of innate and adaptive immunity …