1. INTRODUCTION Nitrogen-containing heterocycles are widely distributed in nature and
essential for life, playing a vital role in the metabolism of all living cells. Among the many …

Amino-pyrazoles have proven to be a class of fascinating and privileged organic tools for the
construction of diverse heterocyclic or fused heterocyclic scaffolds. This review presents …

The condensation of 5-aminopyrazole with various bielectrophilic moieties results in the
formation of pyrazoloazines, an interesting array of fused heterocyclic systems. The …

Pyrazolo [1, 5-a] pyrimidines are the dominant motif of many drugs; for instance, zaleplon
and indiplon are sedative agents and ocinaplon was identified as an anxiolytic agent. The …

In an attempt to find novel α-glucosidase inhibitors, an efficient, straightforward reaction to
synthesize a library of fully substituted 6-amino-pyrazolo [1, 5-a] pyrimidines 3 has been …

A convenient and straightforward regioselective synthesis of pi‐conjugated pyrazolo [1, 5‐a]
pyrimidines has been achieved via Brønsted acidic ionic liquid catalyzed tandem cyclization …

New thiadiazole-pyrazolotriazine and thiadiazole-pyrazolopyrimidine hybrids were
produced by heterocyclization reactions of aminopyrazole-thiadiazole hybrid with various …

A miniaturized assay was optimized to evaluate the enhanced apparent water solubility of
pyrazolo [3, 4-d] pyrimidine derivatives used extensively as anticancer drug scaffolds. The …

A regioselective synthesis of novel pyrazolo [3, 4‐d] pyrimidines, imidazo [1, 2‐b] pyrazoles,
pyrazolo [3, 4‐d][1, 2, 3] triazine, pyrazolo [1, 5‐c][1, 3, 5] triazine and pyrazolo [1, 5‐c][1, 3 …

Pyrazolopyrimidines are a privileged class of 5-6 bicyclic systems with three or four nitrogen
atoms, including four possible isomeric structures. The significance of this class of …