Natural and experimental SARS-CoV-2 infection in domestic and wild animals

DA Meekins, NN Gaudreault, JA Richt - Viruses, 2021 - mdpi.com
SARS-CoV-2 is the etiological agent responsible for the ongoing COVID-19 pandemic,
which continues to spread with devastating effects on global health and socioeconomics …

Choosing a cellular model to study SARS-CoV-2

GA Pires De Souza, M Le Bideau, C Boschi… - Frontiers in cellular …, 2022 - frontiersin.org
As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1

I Khan, S Li, L Tao, C Wang, B Ye, H Li, X Liu… - Nature …, 2024 - nature.com
SARS-CoV-2 and filovirus enter cells via the cell surface angiotensin-converting enzyme 2
(ACE2) or the late-endosome Niemann-Pick C1 (NPC1) as a receptor. Here, we screened …

COVID-19 drug discovery and treatment options

JFW Chan, S Yuan, H Chu, S Sridhar… - Nature Reviews …, 2024 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …

Site-specific glycosylation patterns of the SARS-CoV-2 spike protein derived from recombinant protein and viral WA1 and D614G strains

Y Tian, LM Parsons, E Jankowska, JF Cipollo - Frontiers in chemistry, 2021 - frontiersin.org
The SARS-CoV-2 spike protein is heavily glycosylated, having 22 predicted N-glycosylation
sites per monomer. It is also O-glycosylated, although the number of O-glycosites is less …

Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV across mammals

M Li, J Du, W Liu, Z Li, F Lv, C Hu, Y Dai… - The ISME …, 2023 - academic.oup.com
Exploring wild reservoirs of pathogenic viruses is critical for their long-term control and for
predicting future pandemic scenarios. Here, a comparative in vitro infection analysis was first …

Coronaviruses Use ACE2 Monomers as Entry‐Receptors

P Eiring, T Klein, S Backes, M Streit… - Angewandte Chemie …, 2023 - Wiley Online Library
The angiotensin‐converting enzyme 2 (ACE2) has been identified as entry receptor on cells
enabling binding and infection with the severe acute respiratory syndrome coronavirus 2 …

Differential cell line susceptibility to the SARS-CoV-2 Omicron BA. 1.1 variant of concern

H Dighe, P Sarkale, DY Patil, S Mohandas, AM Shete… - Vaccines, 2022 - mdpi.com
The unique mutations of the SARS-CoV-2 Omicron variant are associated with increased
transmissibility, immune escape, increased binding affinity to ACE-2, and increased viral …

Test accuracy of rapid diagnostic tests and reverse‐transcription polymerase chain reaction against virus isolation in cell culture for assessing SARS‐CoV‐2 infectivity …

A Fomenko, T Dähne, S Weibel… - Reviews in Medical …, 2024 - Wiley Online Library
We aimed to assess the performance of Ag‐RDT and RT‐qPCR with regard to detecting
infectious SARS‐CoV‐2 in cell cultures, as their diagnostic test accuracy (DTA) compared to …

A potent virucidal activity of functionalized TiO2 nanoparticles adsorbed with flavonoids against SARS-CoV-2

G León-Gutiérrez, JE Elste, C Cabello-Gutiérrez… - Applied Microbiology …, 2022 - Springer
The coronavirus SARS-CoV-2 has caused a pandemic with> 550 millions of cases and> 6
millions of deaths worldwide. Medical management of COVID-19 relies on supportive care …