Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

Damage to the central nervous system (CNS) results in a glial reaction, leading eventually to
the formation of a glial scar. In this environment, axon regeneration fails, and remyelination …

Neural stem cells reside in the subventricular zone (SVZ) of the adult mammalian brain. This
germinal region, which continually generates new neurons destined for the olfactory bulb, is …

Although the existence of mammary stem cells has been suggested by serial transplantation
studies in mice, their identification has been hindered by the lack of specific surface markers …

The adult mammalian subventricular zone (SVZ) contains stem cells that give rise to
neurons and glia. In vivo, SVZ progeny migrate 3–8 mm to the olfactory bulb, where they …

Although the concept that cancers arise from “stem cells” or “germ cells” was first proposed
about 150 years ago, it is only recently that advances in stem cell biology have given new …

Stem cells, which are clonogenic cells with self-renewal and multilineage differentiation
properties, have the potential to replace or repair damaged tissue. We have directly isolated …

Stem cells are a valuable resource for treating disease, but limited access to stem cells from
tissues such as brain restricts their utility. Here, we injected marrow stromal cells (MSCs) into …

Recent studies suggest that cancer can arise from a cancer stem cell (CSC), a tumor-
initiating cell that has properties similar to those of stem cells. CSCs have been identified in …

One of the impediments to the treatment of brain tumors (eg, gliomas) has been the degree
to which they expand, infiltrate surrounding tissue, and migrate widely into normal brain …