Congenital heart defects (CHD) include structural abnormalities of the heart or/and great
vessels that are present at birth. CHD affects around 1% of all newborns worldwide …

Rationale: Familial recurrence studies provide strong evidence for a genetic component to
the predisposition to sporadic, nonsyndromic Tetralogy of Fallot (TOF), the most common …

Vascular endothelial growth factor receptors (VEGFRs) are part of the evolutionarily
conserved VEGF signalling pathways that regulate the development and maintenance of the …

Eukaryotic cells often use proteins localized to the ciliary membrane to monitor the
extracellular environment. The mechanism by which proteins are sorted, specifically to this …

Background—Myocardial fibrosis is linked with adverse clinical outcomes in adults after
tetralogy of Fallot repair (rTOF). Native T1 times (T1) by cardiac magnetic resonance have …

Aims Pulmonary regurgitation (PR) is an important determinant of outcome after tetralogy of
Fallot (TOF) repair. The physiologic impact of PR on the right ventricle remains incompletely …

Objective Prenatal imaging has identified alterations of brain growth in fetuses with
congenital heart disease. However, little is known about the timing of altered brain …

Background Although early results of pulmonary valve replacement (PVR) after tetralogy of
Fallot repair have been described, information about late postoperative ventricular size and …

Abstract Background Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart
disease (CCHD) with multifactorial etiology. We aimed to investigate the metabolic profiles …

OBJECTIVE: The tricuspid annular plane systolic excursion (TAPSE) as an
echocardiographic index to assess right ventricular (RV) systolic function has not been …