Background: Thiazole is widely investigated bioactive scaffold and dynamic tool in medicinal
chemistry research. Significance of thiazole compounds are well documented as thiazole is …

Compounds which directly inhibit IRE-1C. activity in vitro, prodrugs, and pharmaceutically
acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases …

Malaria is a disease caused by parasitic protozoa of the genus Plasmodium. Despite
significant advances in understanding the disease and the parasite biology, malaria still …

Introduction: New antimalarials with novel modes of action are crucial in countering the
challenge of emerging drug-resistant Plasmodium falciparum. Equally significant is the …

Compounds Which directly inhibit IRE-10. activity in vitro, prodrugs, and pharmaceutically
acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases …

Compounds and methods are described for producing protein compositions having reduced
amounts of O-linked glycosy lation. The method includes producing the protein in cells …

A6 IK3I/92(200 6. 01) Such compounds and prodrugs are useful for treating diseases A
6LX3L/357(200 6. 01) associated with the unfolded protein response and can be used A6 …

Compounds which directly inhibit IRE-1C. activity in vitro, prodrugs, and pharmaceutically
acceptable salts thereof. Such compounds and prodrugs are useful for treating dis eases …

(60) Continuation of application No. 14/969,837, filed on 4,028,366 A 6/1977 Zenitz Dec. 15,
2015, now Pat. No. 9,546, 149, which is a (Continued) division of application No …

US8765409B2 - Efficient production of heterologous proteins using mannosyl transferase
inhibitors - Google Patents US8765409B2 - Efficient production of heterologous proteins using …