Overcoming antibiotic resistance: the potential and pitfalls of drug repurposing
M Abavisani, A Khoshrou, S Eshaghian… - Journal of Drug …, 2024 - Taylor & Francis
Since its emergence shortly after the discovery of penicillin, antibiotic resistance has
escalated dramatically, posing a significant health threat and economic burden. Drug …
escalated dramatically, posing a significant health threat and economic burden. Drug …
Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction
LSM-83177, a phenoxy acetic acid derivative, is a small molecule reported for its promising
anti-tumor properties. Via inhibiting the interaction between MDM2 and p53, LSM-83177 can …
anti-tumor properties. Via inhibiting the interaction between MDM2 and p53, LSM-83177 can …
[HTML][HTML] Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio …
Molecules | Free Full-Text | Design, Synthesis, and Biological Evaluation of Novel Phenoxy
Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological …
Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological …
Crotalaria madurensis flavonol glycosides' antibacterial activity against Staphylococcus aureus
HS Mohammed, SA Abu El Wafa, MH Ibrahim… - AMB Express, 2024 - Springer
Methicillin-resistant Staphylococcus aureus (MRSA) infections are prevalent in hospitals and
often lead to significant health complications. This study aimed to explore the chemical …
often lead to significant health complications. This study aimed to explore the chemical …
A novel strategy to bind pyrimidine sulfonamide derivatives with odd even chains: exploration of their design, synthesis and biological activity evaluation
M Zhou, Y Liu, S Wang, J Feng, H Ni, C Lu, G Jin - Molecular Diversity, 2023 - Springer
Based on the hybridization strategy of dominant fragments, a series of pyrimidine
sulfonamide (PS) derivatives were obtained by combining the pharmacophore fragments …
sulfonamide (PS) derivatives were obtained by combining the pharmacophore fragments …
Synthesis, nanostructuring and in silico studies of a new imine bond containing a macroheterocycle as a promising PBP-2a non-β-lactam inhibitor
A Huseynzada, M Aghayev, S Hajiyeva… - Journal of Materials …, 2023 - pubs.rsc.org
This study is devoted to the synthesis of a 40-membered macroheterocycle with its further
nanostructuring by magnetite nanoparticles. The mentioned macroheterocycle was …
nanostructuring by magnetite nanoparticles. The mentioned macroheterocycle was …
New N-amino-5-cyano-6-pyridones as antimicrobial small molecules endowed with DNA gyrase a inhibitory activity: design, one-pot synthesis, biological assessment …
A set of innovative N-amino-5-cyano-6-pyridones derivatives was developed and produced
using one-pot three-component procedures. The evaluated molecules were examined for …
using one-pot three-component procedures. The evaluated molecules were examined for …
Chemical composition's effect on Solanum nigrum Linn.'s antioxidant capacity and erythrocyte protection: Bioactive components and molecular docking analysis
A Aouadi, DH Saoud, A Rebiai, MH Ibrahim… - Open Life …, 2024 - degruyter.com
Oxidative stress has been widely believed to be the mechanism responsible for developing
diseases such as arthritis, asthma, dementia, and aging. Solanum nigrum Linn. is a common …
diseases such as arthritis, asthma, dementia, and aging. Solanum nigrum Linn. is a common …