Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …

Adenosine is a purine nucleoside, responsible for the regulation of a wide range of
physiological and pathophysiological conditions by binding with four G-protein-coupled …

Adenosine is an endogenous purine nucleoside ubiquitously distributed throughout the
body that interacts with G protein-coupled receptors, classified in four subtypes: A 1 R, A 2A …

Adenosine, the purine nucleoside, mediates its effects through activation of four G-protein
coupled adenosine receptors (ARs) named as A 1, A 2A, A 2B and A 3. In particular, A 1 ARs …

Retinal injuries and diseases are major causes of human disability involving vision
impairment by the progressive and permanent loss of retinal neurons. During development …

Retinopathy of prematurity (ROP) is a major cause of childhood blindness in the world and is
caused by oxygen-induced damage to the developing retinal vasculature, resulting in …

Ischemia is characterized by a transient, insufficient, or permanent interruption of blood flow
to a tissue, which leads to an inadequate glucose and oxygen supply. The nervous tissue is …

Emerging evidence indicates that adenosine is a major regulator of striatum activity, in part,
through the antagonistic modulation of dopaminergic function. Exercise can influence …

Caffeine is the most consumed psychostimulant drug in the world, acting as a non-selective
antagonist of adenosine receptors A 1 R and A 2A R, which are widely expressed in retinal …

Adenosine is an important neuroactive substance in the central nervous system, including in
the retina where subclasses of adenosine receptors and transporters are expressed since …