Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

On July 2–3, 1996, the National Heart, Lung, and Blood Institute sponsored a workshop in
Columbia, Md, entitled “The Medical and Cellular Implications of Myocardial Stunning …

Ischemic preconditioning, a powerful form of endogenous protection against myocardial
infarction, has been demonstrated in several animal species and, recently, in isolated …

Following a period of ischemia (local restriction of blood supply to a tissue), the restoration of
blood supply to the affected area causes significant tissue damage. This is known as …

The purine nucleoside adenosine is an important regulator within the cardiovascular system,
and throughout the body. Released in response to perturbations in energy state, among …

Brief transient episodes of nonlethal myocardial ischemia protect or “precondition” the heart
and render the myocardium resistant to a subsequent more sustained ischemic insult. The …

The possibility that an innate mechanism of myocardial protection might be inducible in the
human heart has generated considerable excitement and enthusiastic research. The …

When the heart is subjected to a transient nonlethal period of ischemia, it quickly adapts
itself to become resistant to infarction from a subsequent ischemic insult. This adaptation is …