T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …

Clonal selection and drift drive both normal tissue and cancer development. However, the
biological mechanisms and environmental conditions underpinning these processes remain …

Abstract Interleukin-7 (IL-7) supports the growth and chemoresistance of T-cell acute
lymphoblastic leukemia (T-ALL), particularly the early T-cell precursor subtype (ETP-ALL) …

Relapse in T-cell acute lymphoblastic leukemia (T-ALL) may signify the persistence of
leukemia-initiating cells (L-ICs). Ectopic TAL1/LMO expression defines the largest subset of …

B cell acute lymphoblastic leukemia (B-ALL) is a multistep disease characterized by the
hierarchical acquisition of genetic alterations. However, the question of how a primary …

Intensive chemotherapy for acute leukemia can usually induce complete remission, but fails
in many patients to eradicate the leukemia stem cells responsible for relapse. There is …

Colorectal cancer (CRC) is one of the most common malignancies, and chemoresistance is
one of the key obstacles in the clinical outcome. Here, we studied the function of B7-H3 in …

Chemoresistance posts a major hurdle for treatment of acute leukemia. There is increasing
evidence that prolonged and intensive chemotherapy often fails to eradicate leukemic stem …

Abstract Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is an immature
subtype of T-cell acute lymphoblastic leukemia (T-ALL) commonly show deregulation of the …

Background Acute myeloid leukemia (AML) is a hematopoietic malignancy with a prognosis
that varies with genetic heterogeneity of hematopoietic stem/progenitor cells (HSPCs) …