Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …
membranes and associated proteins are linked to the thermodynamics and kinetics of …
[HTML][HTML] Limitations and challenges in protein stability prediction upon genome variations: towards future applications in precision medicine
Protein stability predictions are becoming essential in medicine to develop novel
immunotherapeutic agents and for drug discovery. Despite the large number of …
immunotherapeutic agents and for drug discovery. Despite the large number of …
Loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure
Most known pathogenic mutations occur in protein-coding regions of DNA and change the
way proteins are made. Taking protein structure into account has therefore provided great …
way proteins are made. Taking protein structure into account has therefore provided great …
PremPS: Predicting the impact of missense mutations on protein stability
Y Chen, H Lu, N Zhang, Z Zhu, S Wang… - PLoS computational …, 2020 - journals.plos.org
Computational methods that predict protein stability changes induced by missense
mutations have made a lot of progress over the past decades. Most of the available methods …
mutations have made a lot of progress over the past decades. Most of the available methods …
ProThermDB: thermodynamic database for proteins and mutants revisited after 15 years
ProThermDB is an updated version of the thermodynamic database for proteins and mutants
(ProTherm), which has∼ 31 500 data on protein stability, an increase of 84% from the …
(ProTherm), which has∼ 31 500 data on protein stability, an increase of 84% from the …
Rapid protein stability prediction using deep learning representations
Predicting the thermodynamic stability of proteins is a common and widely used step in
protein engineering, and when elucidating the molecular mechanisms behind evolution and …
protein engineering, and when elucidating the molecular mechanisms behind evolution and …
DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach
Cancer genome and other sequencing initiatives are generating extensive data on non-
synonymous single nucleotide polymorphisms (nsSNPs) in human and other genomes. In …
synonymous single nucleotide polymorphisms (nsSNPs) in human and other genomes. In …
Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation
Understanding and predicting the functional consequences of single amino acid changes is
central in many areas of protein science. Here, we collect and analyze experimental …
central in many areas of protein science. Here, we collect and analyze experimental …
WS-SNPs&GO: a web server for predicting the deleterious effect of human protein variants using functional annotation
Background SNPs&GO is a method for the prediction of deleterious Single Amino acid
Polymorphisms (SAPs) using protein functional annotation. In this work, we present the web …
Polymorphisms (SAPs) using protein functional annotation. In this work, we present the web …
Solvent accessibility of residues undergoing pathogenic variations in humans: from protein structures to protein sequences
C Savojardo, M Manfredi, PL Martelli… - Frontiers in molecular …, 2021 - frontiersin.org
Solvent accessibility (SASA) is a key feature of proteins for determining their folding and
stability. SASA is computed from protein structures with different algorithms, and from protein …
stability. SASA is computed from protein structures with different algorithms, and from protein …