Introduction: The hybridization of biologically active molecules is a powerful tool for drug
discovery used to target a variety of diseases. It offers the prospect of better drugs for the …

Piperazine is one of the most sought heterocyclics for the development of new drug
candidates. This ring can be traced in a number of well established, commercially available …

Tuberculosis, an infectious disease, has been reported to cause the death of 1.5 million in
2018. Due to the emergence of Multi-Drug Resistant-TB, Extensively Drug Resistant-TB, and …

Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …

Abstract Since 2011 Direct Acting antivirals (DAAs) drugs targeting different non-structural
(NS) viral proteins (NS3, NS5A or NS5B inhibitors) have been approved for clinical use in …

Aims: The study aims to synthesize bioactive hybrid pharmacophores (thiazole ring and
imidazo [2, 1-b] thiazole system) by incorporating them into one biological assessment …

Finding high quality beginning compounds is a critical job at the start of the lead generation
stage for multi-target drug discovery (MTDD). Designing hybrid compounds as selective …

Abstract A series of 1-[aryl-(thiazol-2-ylamino)-methyl]-naphthalen-2-ol derivatives were
synthesized using porcine pancreatic lipase as a catalyst. The major assets of this …

A series of 3-[(4-aryl-2-thiazolyl) hydrazone]-1H-indol-2, 3-dione derivatives (2a-f) were
designed and synthesized using isatin as starting material. The obtained thiazole …

Tuberculosis (TB) accounts for millions of deaths worldwide every year. Diverse survival
strategies adopted by Mycobacterium tuberculosis (Mtb) have substantially hindered the …