The present paper was extensively discussed during a Workshop on “Threshold of
Toxicological Concern for Chemical Substances Present in the Diet”, held in Paris on 5–6 …

Ototoxicity is a major cause of the loss of hearing and balance in humans. Ototoxic
compounds include pharmaceuticals such as aminoglycoside antibiotics, anti-malarial …

Alzheimer's disease is a complex disorder whose etiology is still controversial. It is proposed
that vestibular loss may contribute to the onset of Alzheimer's disease, which initially …

Several animal models of vestibular deficits that mimic the human pathology phenotype
have previously been developed to correlate the degree of vestibular injury to cognate …

BACKGROUND AND PURPOSE Betahistine, the main histamine drug prescribed to treat
vestibular disorders, is a histamine H3 receptor antagonist. Here, we explored the potential …

Hypergravity disrupts the circadian regulation of temperature (Temp) and locomotor activity
(Act) mediated through the vestibular otolithic system in mice. In contrast, we do not know …

Abstract Adult male Long-Evans rats (250–350 g) received control vehicles, 3, 3′-
iminodipropionitrile (IDPN, 400 mg kg− 1 day− 1), allylnitrile (50 mg kg− 1 day− 1), cis …

In stargazer mutant mice, a mutation in the gene encoding stargazin results in absence
epilepsy, cerebellar ataxia, and a characteristic abnormal motor syndrome. The main goal of …

Ototoxicity is known to cause permanent loss of vestibule function through degeneration of
sensory hair cells (HCs). However, functional recovery has been reported during washout …

Damage to inner ear afferent terminals is believed to result in many auditory and vestibular
dysfunctions. The sequence of afferent injuries and repair, as well as their correlation with …