RNA has diverse cellular functionality, including regulating gene expression, protein
translation, and cellular response to stimuli, due to its intricate structures. Over the past …

Highlights•Conformational penalties to form alternative conformational states of nucleic
acids greatly contribute to nucleic acid-protein recognition.•Methods to determine nucleic …

RNA's ability to form and interconvert between multiple secondary and tertiary structures is
critical to its functional versatility and the traditional view of RNA structures as static entities …

Elucidating how damage impacts DNA dynamics is essential for understanding the
mechanisms of damage recognition and repair. Many DNA lesions alter their propensities to …

Excited-ground-state transition and strand slippage of RNA play key roles in transcription
and translation of central dogma. Due to limitation of current experimental techniques, the …

Riboswitches regulate downstream gene expression by binding to specific small molecules
or ions with multiple mechanisms to transfer the binding information. In the case of the …

RNA conformational dynamics is pivotal for functional regulations in biology. RNA can
function as versatile as protein but adopts multiple distinct structures. In this review, we …

This study presents efficient synthetic pathways for preparing novel azaspirocycles. These
methodologies involve functionalizing key bicyclic hydrazines with a substituent on one of …

This chapter explores current theoretical and experimental trends in nuclear spin relaxation,
providing a digest of around 100 research papers published between 2022 and mid 2023 …

Biologia strukturalna zajmuje się poznawaniem budowy biocząsteczek, takich jak białka i
kwasy nukleinowe. Rozszyfrowanie struktury pozwala na zrozumienie ich funkcjonowania w …