Single-molecule visualization of human A2A adenosine receptor activation by a G protein and constitutively activating mutations
Mutations that constitutively activate G protein-coupled receptors (GPCRs), known as
constitutively activating mutations (CAMs), modify cell signaling and interfere with drugs …
constitutively activating mutations (CAMs), modify cell signaling and interfere with drugs …
Binding kinetics drive G protein subtype selectivity at the β1-adrenergic receptor
G protein-coupled receptors (GPCRs) bind to different G protein α-subtypes with varying
degrees of selectivity. The mechanism by which GPCRs achieve this selectivity is still …
degrees of selectivity. The mechanism by which GPCRs achieve this selectivity is still …
[HTML][HTML] Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies
A Fouillen, P Couvineau, G Gaibelet, S Riché… - Computational and …, 2024 - Elsevier
G protein-coupled receptors (GPCRs) control critical cell signaling. Their response to
extracellular stimuli involves conformational changes to convey signals to intracellular …
extracellular stimuli involves conformational changes to convey signals to intracellular …
Minute-timescale free-energy calculations reveal a pseudo-active state in the adenosine A2A receptor activation mechanism
G protein-coupled receptors (GPCRs) are membrane proteins targeted by over one-third of
marketed drugs. Understanding their activation mechanism is essential for precise …
marketed drugs. Understanding their activation mechanism is essential for precise …
Minute-timescale simulations of G Protein Coupled Receptor A2A activation mechanism reveal a receptor pseudo-active state
ABSTRACT G protein coupled receptors (GPCRs) are membrane proteins of greatest
pharmacological relevance, targeted by over one third of marketed drugs. These receptors …
pharmacological relevance, targeted by over one third of marketed drugs. These receptors …
Advances in NMR spectroscopy of small molecules in solution
P Nolis - 2023 - books.rsc.org
This book chapter covers relevant articles published in peer-reviewed journals in 2022 in
the field of NMR spectroscopy of small molecules in solution. Articles that appeared in 2022 …
the field of NMR spectroscopy of small molecules in solution. Articles that appeared in 2022 …
NMR of proteins and nucleic acids
RA Atkinson - 2021 - books.rsc.org
A review of key publications from 2020, describing methodological developments and
research applications of NMR of proteins and nucleic acids. Particularly novel approaches …
research applications of NMR of proteins and nucleic acids. Particularly novel approaches …
Structurally similar G protein complexes with β1-adrenergic receptor active state show differential binding kinetics, mediating selectivity
D Nietlispach, A Jones, T Harman, M Harris, O Lewis… - 2023 - researchsquare.com
G protein-coupled receptors (GPCRs) bind to different G protein α-subtypes with varying
degrees of selectivity. The mechanism by which GPCRs achieve this selectivity is still …
degrees of selectivity. The mechanism by which GPCRs achieve this selectivity is still …
Understanding the Conformational Dynamics of the A2A Adenosine Receptor by Single-Molecule Fluorescence
S Wei - 2024 - trace.tennessee.edu
G protein-coupled receptors (GPCRs) are one of the largest transmembrane receptor
families. The wide expression and diverse signal transduction functions make them an ideal …
families. The wide expression and diverse signal transduction functions make them an ideal …