Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Men and women often experience different symptoms or rates of occurrence for a variety of
mood disorders. Many of the symptoms of mood disorders overlap with autoimmune …

Quercetin is a polyphenol with multiple biological activities, and results of our preliminary
study showed that it could shorten the immobility time of mice in the forced swimming test …

To investigate the mechanism of cyclooxygenase 2 (COX2) in learning and memory
impairments in rats subjected to chronic unpredictable mild stress (CUMS), meloxicam was …

Stress refers to a dynamic process in which the homeostasis of an organism is challenged,
the outcome depending on the type, severity, and duration of stressors involved, the stress …

Given the moderate efficacy of the currently available antidepressants (ADs) in the treatment
of major depressive disorder (MDD), the identification of agents that are both able to …

Background. Neuroinflammation has been implicated in depression. Nonsteroidal anti-
inflammatory drugs (NSAIDs) have been found effective in treating animal models of …

Systemic inflammation causes malaise and general feelings of discomfort. This fundamental
aspect of the sickness response reduces the quality of life for people suffering from chronic …

Millions of individuals worldwide suffers from mood disorders, especially major depressive
disorder (MDD), which has a high rate of disease burden in society. Although targeting the …

Simultaneous relief of the pain from body and brain remains an ongoing challenge. The aim
of the present study was to clarify whether plant-derived isoflavone puerarin could …