Anticancer drugs continue to cause significant reductions in left ventricular ejection fraction
resulting in congestive heart failure. The best-known cardiotoxic agents are anthracyclines …

Survivin, an inhibitor of apoptosis protein, is highly expressed in most cancers and
associated with chemotherapy resistance, increased tumor recurrence, and shorter patient …

Besides gene-editing, the CRISPR/Cas12a system has also been widely used in in vitro
biosensing, but its applications in live-cell biosensing are rare. One reason is lacking …

Apoptosis is a crucial biological process that prevents uncontrolled cell proliferation and
eliminates harmful cells. Resistance to apoptotic stimuli is a hallmark feature of various …

Growing evidence suggests that survivin expression in cancer cell nuclei may represent an
important prognostic marker to predict disease outcome for cancer patients. Current reports …

Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of
locally advanced disease generally requires various combinations of radiotherapy, surgery …

Plasma membrane proteins that are exposed on the cell surface have important biological
functions, such as signaling into and out of the cells, ion transport, and cell-cell and cell …

Resistance to chemotherapy drugs is a major problem in cancer treatment. Scientific
advances made in the last two decades have resulted in the identification of genes and …

Although the lipid mediator prostaglandin E 2 (PGE 2) exerts antifibrotic effects by inhibiting
multiple fibroblast functions, its ability to regulate fibroblast survival is unknown. Here, we …

A growing body of evidence indicates that digitoxin cardiac glycoside is a promising
anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half …