The multifaced role of HtrA1 in the development of joint and skeletal disorders
G Tossetta, S Fantone, C Licini, D Marzioni… - Bone, 2022 - Elsevier
HtrA1 (High temperature requirement A1) family proteins include four members, widely
conserved from prokaryotes to eukaryotes, named HtrA1, HtrA2, HtrA3 and HtrA4. HtrA1 is a …
conserved from prokaryotes to eukaryotes, named HtrA1, HtrA2, HtrA3 and HtrA4. HtrA1 is a …
Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers
R Campagna, V Pozzi, D Sartini, E Salvolini… - Cancers, 2021 - mdpi.com
Simple Summary Skin cancers (SC) are a frequent type of malignancy in white populations
and include malignant melanoma and non-melanoma skin cancer. Due to their increasing …
and include malignant melanoma and non-melanoma skin cancer. Due to their increasing …
Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response
Diverse subtypes of renal cell carcinomas (RCCs) display a wide spectrum of
histomorphologies, proteogenomic alterations, immune cell infiltration patterns, and clinical …
histomorphologies, proteogenomic alterations, immune cell infiltration patterns, and clinical …
[HTML][HTML] Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury
R Campagna, Ł Mateuszuk, K Wojnar-Lason… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Nicotinamide N-methyltransferase (NNMT, EC 2.1. 1.1.) plays an important role in
the growth of many different tumours and is also involved in various non-neoplastic …
the growth of many different tumours and is also involved in various non-neoplastic …
Nicotinamide N‐methyltransferase gene silencing enhances chemosensitivity of melanoma cell lines
R Campagna, E Salvolini, V Pompei… - Pigment Cell & …, 2021 - Wiley Online Library
Melanoma accounts for less than 5% of all cutaneous neoplasms but is responsible for the
greater part of skin cancer–related deaths. Therefore, the identification of molecules that …
greater part of skin cancer–related deaths. Therefore, the identification of molecules that …
Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma
A Reustle, LS Menig, P Leuthold… - Clinical and …, 2022 - Wiley Online Library
Background The metabolic enzyme nicotinamide‐N‐methyltransferase (NNMT) is highly
expressed in various cancer entities, suggesting tumour‐promoting functions. We …
expressed in various cancer entities, suggesting tumour‐promoting functions. We …
The Utility of Nicotinamide N-methyltransferase as a potential biomarker to predict the oncological outcomes for urological cancers: an update
R Campagna, V Pozzi, G Spinelli, D Sartini, G Milanese… - Biomolecules, 2021 - mdpi.com
Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation reaction of
nicotinamide, using S-adenosyl-L-methionine as the methyl donor. Enzyme overexpression …
nicotinamide, using S-adenosyl-L-methionine as the methyl donor. Enzyme overexpression …
Elevated N‐methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 …
J Li, S You, S Zhang, Q Hu, F Wang, X Chi… - Molecular …, 2019 - Wiley Online Library
The cross‐talk between hepatic stellate cells (HSCs) and hepatic carcinoma cells
contributes to hepatocellular carcinoma (HCC) progression, but the underlying mechanism …
contributes to hepatocellular carcinoma (HCC) progression, but the underlying mechanism …
HTRA family proteins in pregnancy outcome
S Fantone, SR Giannubilo, D Marzioni, G Tossetta - Tissue and Cell, 2021 - Elsevier
HTRA (High temperature requirement protease A) family proteins includes HTRA1 (L56 or
PRSS11), HTRA2/Omi, HTRA3 (PRSP) and HTRA4. These are oligomeric serine proteases …
PRSS11), HTRA2/Omi, HTRA3 (PRSP) and HTRA4. These are oligomeric serine proteases …
Targeting nicotinamide N‐methyltransferase decreased aggressiveness of osteosarcoma cells
EN Serritelli, D Sartini, R Campagna… - European Journal of …, 2024 - Wiley Online Library
Background Osteosarcoma (OS) is a primary bone malignancy that mostly affects young
people, characterized by high metastatic potential, and a marked chemoresistance that is …
people, characterized by high metastatic potential, and a marked chemoresistance that is …