Structural biology of SARS-CoV-2: open the door for novel therapies
W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
SARS-CoV-2-specific immune response and the pathogenesis of COVID-19
E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …
Therapeutic anticoagulation with heparin in noncritically ill patients with Covid-19
ATTACC, ACTIV-4a, and REMAP-CAP … - New England Journal …, 2021 - Mass Medical Soc
Background Thrombosis and inflammation may contribute to the risk of death and
complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized …
complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized …
SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2
TM Clausen, DR Sandoval, CB Spliid, J Pihl… - Cell, 2020 - cell.com
We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and
angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD) …
angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD) …
Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a
pandemic and continues to spread around the globe at an unprecedented rate. To date, no …
pandemic and continues to spread around the globe at an unprecedented rate. To date, no …
Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro
Dear Editor, COVID-19, caused by the SARS-CoV-2 virus, has now spread worldwide with
catastrophic human and economic impacts and currently has infected over 10 million people …
catastrophic human and economic impacts and currently has infected over 10 million people …
Cardiovascular disease and COVID-19: a consensus paper from the ESC working group on coronary pathophysiology & microcirculation, ESC working group on …
E Cenko, L Badimon, R Bugiardini… - Cardiovascular …, 2021 - academic.oup.com
The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19).
Microvascular injury, endothelial dysfunction, and thrombosis resulting from viral infection or …
Microvascular injury, endothelial dysfunction, and thrombosis resulting from viral infection or …
BeStSel: webserver for secondary structure and fold prediction for protein CD spectroscopy
Circular dichroism (CD) spectroscopy is widely used to characterize the secondary structure
composition of proteins. To derive accurate and detailed structural information from the CD …
composition of proteins. To derive accurate and detailed structural information from the CD …
The SARS-COV-2 spike protein binds sialic acids and enables rapid detection in a lateral flow point of care diagnostic device
There is an urgent need to understand the behavior of the novel coronavirus (SARS-COV-2),
which is the causative agent of COVID-19, and to develop point-of-care diagnostics. Here, a …
which is the causative agent of COVID-19, and to develop point-of-care diagnostics. Here, a …
SARS-CoV-2 antiviral therapy
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …
vaccination, as well as for those who do not respond robustly to vaccination. This review …