Meta-hallmarks of aging and cancer
Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
Senescence and cancer—role and therapeutic opportunities
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
[HTML][HTML] Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming
R Mattioli, A Ilari, B Colotti, L Mosca, F Fazi… - Molecular Aspects of …, 2023 - Elsevier
Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …
since their discovery. However, their use in therapy has been complicated by severe side …
Cellular senescence: aging, cancer, and injury
Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …
Unmasking senescence: context-dependent effects of SASP in cancer
Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …
culture artefact by some researchers, senescence is now a major field of study. Although …
The complexity of p53-mediated metabolic regulation in tumor suppression
Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …
and apoptosis are well accepted as critical barriers to cancer development, accumulating …
p53 in survival, death and metabolic health: a lifeguard with a licence to kill
F Kruiswijk, CF Labuschagne… - Nature reviews Molecular …, 2015 - nature.com
The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …
[HTML][HTML] Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression
Oncogene-induced senescence causes hepatocytes to secrete cytokines, which induce their
immune-mediated clearance to prevent tumor initiation, a process termed" senescence …
immune-mediated clearance to prevent tumor initiation, a process termed" senescence …
Immunosenescence in aging: between immune cells depletion and cytokines up-regulation
MT Ventura, M Casciaro, S Gangemi… - Clinical and Molecular …, 2017 - Springer
Background The immunosenescence is a relatively recent chapter, correlated with the linear
extension of the average life began in the nineteenth century and still in progress. The most …
extension of the average life began in the nineteenth century and still in progress. The most …
[HTML][HTML] Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early …
A Goldhirsch, EP Winer, AS Coates, RD Gelber… - Annals of oncology, 2013 - Elsevier
Abstract The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel
reviewed and endorsed substantial new evidence on aspects of the local and regional …
reviewed and endorsed substantial new evidence on aspects of the local and regional …