Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system
M Aryal, CD Arvanitis, PM Alexander… - Advanced drug delivery …, 2014 - Elsevier
The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
Ultrasound treatment of neurological diseases—current and emerging applications
Like cardiovascular disease and cancer, neurological disorders present an increasing
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation
ZI Kovacs, S Kim, N Jikaria, F Qureshi… - Proceedings of the …, 2017 - National Acad Sciences
MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of
ultrasound contrast agent microbubbles (MB) causes localized blood–brain barrier (BBB) …
ultrasound contrast agent microbubbles (MB) causes localized blood–brain barrier (BBB) …
Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: a meta-analysis of 52 studies
Background The neurotrophic hypothesis postulates that mood disorders such as bipolar
disorder (BD) are associated with a lower expression of brain-derived neurotrophic factor …
disorder (BD) are associated with a lower expression of brain-derived neurotrophic factor …
Minimally invasive and regenerative therapeutics
Advances in biomaterial synthesis and fabrication, stem cell biology, bioimaging,
microsurgery procedures, and microscale technologies have made minimally invasive …
microsurgery procedures, and microscale technologies have made minimally invasive …
The size of blood–brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure
H Chen, EE Konofagou - Journal of Cerebral Blood Flow & …, 2014 - journals.sagepub.com
Focused ultrasound (FUS) in combination with microbubbles (MBs) has been successfully
used in the delivery of various-size therapeutic agents across the blood–brain barrier (BBB) …
used in the delivery of various-size therapeutic agents across the blood–brain barrier (BBB) …
Drug and gene delivery across the blood–brain barrier with focused ultrasound
The blood–brain barrier (BBB) remains one of the most significant limitations to treatments of
central nervous system (CNS) disorders including brain tumors, neurodegenerative …
central nervous system (CNS) disorders including brain tumors, neurodegenerative …
Long-term safety of repeated blood-brain barrier opening via focused ultrasound with microbubbles in non-human primates performing a cognitive task
Focused Ultrasound (FUS) coupled with intravenous administration of microbubbles (MB) is
a non-invasive technique that has been shown to reliably open (increase the permeability …
a non-invasive technique that has been shown to reliably open (increase the permeability …
Cavitation-modulated inflammatory response following focused ultrasound blood-brain barrier opening
Focused ultrasound (FUS) in combination with systemically injected microbubbles can be
used to non-invasively open the blood-brain barrier (BBB) in targeted regions for a variety of …
used to non-invasively open the blood-brain barrier (BBB) in targeted regions for a variety of …
Ultrasound-induced blood-brain barrier opening
Over 4 million US men and women suffer from Alzheimer's disease; 1 million from
Parkinson's disease; 350,000 from multiple sclerosis (MS); and 20,000 from amyotrophic …
Parkinson's disease; 350,000 from multiple sclerosis (MS); and 20,000 from amyotrophic …