Current state and challenges in developing oral vaccines

JEV Ramirez, LA Sharpe, NA Peppas - Advanced drug delivery reviews, 2017 - Elsevier
While vaccination remains the most cost effective strategy for disease prevention,
communicable diseases persist as the second leading cause of death worldwide. There is a …

Safety of nanoparticles in medicine

J Wolfram, M Zhu, Y Yang, J Shen, E Gentile… - Current drug …, 2015 - ingentaconnect.com
Nanomedicine involves the use of nanoparticles for therapeutic and diagnostic purposes.
During the past two decades, a growing number of nanomedicines have received regulatory …

Biomedical applications of biodegradable polymers

BD Ulery, LS Nair, CT Laurencin - Journal of polymer science …, 2011 - Wiley Online Library
Utilization of polymers as biomaterials has greatly impacted the advancement of modern
medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant …

Engineering DNA vaccines against infectious diseases

J Lee, SA Kumar, YY Jhan, CJ Bishop - Acta Biomaterialia, 2018 - Elsevier
Engineering vaccine-based therapeutics for infectious diseases is highly challenging, as
trial formulations are often found to be nonspecific, ineffective, thermally or hydrolytically …

Peptide-based vaccines for tuberculosis

W Gong, C Pan, P Cheng, J Wang, G Zhao… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

Metal‐based nanoparticles and the immune system: activation, inflammation, and potential applications

YH Luo, LW Chang, P Lin - BioMed research international, 2015 - Wiley Online Library
Nanomaterials, including metal‐based nanoparticles, are used for various biological and
medical applications. However, metals affect immune functions in many animal species …

Biodegradable nanoparticles as vaccine adjuvants and delivery systems: regulation of immune responses by nanoparticle-based vaccine

T Akagi, M Baba, M Akashi - Polymers in nanomedicine, 2012 - Springer
Polymeric nano-and microparticles have recently been shown to possess significant
potential as drug delivery systems. In particular, the use of biodegradable polymeric …

Polymers for medical and tissue engineering applications

D Ozdil, HM Aydin - Journal of Chemical Technology & …, 2014 - Wiley Online Library
Recent decades have seen great advancements in medical research into materials, both
natural and synthetic, that facilitate the repair and regeneration of compromised tissues …

Self-adjuvanting cancer nanovaccines

Z Liao, J Huang, PC Lo, JF Lovell, H Jin… - Journal of …, 2022 - Springer
Nanovaccines, a new generation of vaccines that use nanoparticles as carriers and/or
adjuvants, have been widely used in the prevention and treatment of various diseases …

Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines

SL Demento, AL Siefert, A Bandyopadhyay… - Trends in …, 2011 - cell.com
Vaccine development has progressed significantly and has moved from whole
microorganisms to subunit vaccines that contain only their antigenic proteins. Subunit …