LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?

T Singer, MJ McConnell, MCN Marchetto… - Trends in …, 2010 - cell.com
LINE-1 (L1) elements are retrotransposons that insert extra copies of themselves throughout
the genome using a 'copy and paste'mechanism. L1s comprise nearly∼ 20% of the human …

Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health

VP Belancio, DJ Hedges, P Deininger - Genome research, 2008 - genome.cshlp.org
Transposable elements (TEs) have shared an exceptionally long coexistence with their host
organisms and have come to occupy a significant fraction of eukaryotic genomes. The bulk …

[PDF][PDF] Environmental exposures and gene regulation in disease etiology

TM Edwards, JP Myers - Ciencia & saude coletiva, 2008 - SciELO Public Health
Health or disease is shaped for all individuals by interactions between their genes and
environment. Exactly how the environment changes gene expression and how this can lead …

Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity: a literature review

KS Cameron, V Buchner, PB Tchounwou - 2011 - degruyter.com
Nickel, a naturally occurring element that exists in various mineral forms, is mainly found in
soil and sediment, and its mobilization is influenced by the physicochemical properties of the …

Transposable elements: major players in shaping genomic and evolutionary patterns

N Colonna Romano, L Fanti - Cells, 2022 - mdpi.com
Transposable elements (TEs) are ubiquitous genetic elements, able to jump from one
location of the genome to another, in all organisms. For this reason, on the one hand, TEs …

All y'all need to know 'bout retroelements in cancer

VP Belancio, AM Roy-Engel, PL Deininger - Seminars in cancer biology, 2010 - Elsevier
Genetic instability is one of the principal hallmarks and causative factors in cancer. Human
transposable elements (TE) have been reported to cause human diseases, including …

Response of transposable elements to environmental stressors

IR Miousse, MCG Chalbot, A Lumen… - … Research/Reviews in …, 2015 - Elsevier
Transposable elements (TEs) comprise a group of repetitive sequences that bring positive,
negative, as well as neutral effects to the host organism. Earlier considered as “junk DNA,” …

piRNA involvement in genome stability and human cancer

M Moyano, G Stefani - Journal of hematology & oncology, 2015 - Springer
PIWI-interacting RNAs (piRNAs) are a large family of small, single-stranded, non-coding
RNAs present throughout the animal kingdom. They form complexes with several members …

Jumping genes and epigenetics: towards new species

R Rebollo, B Horard, B Hubert, C Vieira - Gene, 2010 - Elsevier
Transposable elements (TEs) are responsible for rapid genome remodelling by the creation
of new regulatory gene networks and chromosome restructuring. TEs are often regulated by …

NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression

CH Switzer, HJ Cho, TR Eykyn… - Proceedings of the …, 2022 - National Acad Sciences
Inducible nitric oxide synthase (NOS2) produces high local concentrations of nitric oxide
(NO), and its expression is associated with inflammation, cellular stress signals, and cellular …