Burrowing behaviour is used to assess pain-associated behaviour in laboratory rodents. To
gain insight into how models of disease-associated persistent pain and analgesics affect …

Objective: Existing strategies to identify relevant studies for systematic review may not
perform equally well across research domains. We compare four approaches based on …

Objective Neonatal encephalopathy (NE) is an important cause of mortality and disability
worldwide. Therapeutic hypothermia (HT) is an effective therapy, however not all babies …

Open Science (OS) aims, in part, to drive greater societal impact of academic research.
Government, funder and institutional policies state that it should further democratize …

We sought to apply natural language processing to the task of automatic risk of bias
assessment in preclinical literature, which could speed the process of systematic review …

Systematic reviews and meta-analysis are the cornerstones of evidence-based decision
making and priority setting. However, traditional systematic reviews are time and labour …

Electroconvulsive shocks (ECS) and ketamine are antidepressant treatments with a
relatively fast onset of therapeutic effects compared to conventional medication and …

Metaresearch is a scientific field involving the study of research itself. It has been applied to
clinical trials since the 1980s, 1 but has only become an emerging discipline over the last …

To the Editor—The animal research community is drowning in a sea of publications. Artificial
intelligence (AI) could be the lifeboat needed to stay afloat by fostering a “publomics” …

Robust preclinical models are inevitable for researchers to unravel pathomechanisms of
subarachnoidal hemorrhage (SAH). For the mouse perforation model of SAH, the goal of this …