The global prevalence of myopia, or nearsightedness, has increased at an alarming rate
over the last few decades. An eye is myopic if incoming light focuses prior to reaching the …

Purpose: The International Myopia Institute (IMI) Yearly Digest highlights new research
considered to be of importance since the publication of the first series of IMI white papers …

Purpose Recently, an increasing number of studies relied on the assumption that visually
induced changes in choroidal thickness can serve as a proxy to predict future axial eye …

Myopia is the most common developmental disorder of juvenile eyes, and it has become an
increasing cause of severe visual impairment. The GJD2 locus has been consistently …

Purpose: To determine the acute effect of caffeine intake on the retinal responses as
measured with a global-flash multifocal electroretinogram (gfmERG) protocol at different …

Purpose Myopia is associated with an increased risk of permanent vision loss. The caffeine
metabolite 7-methylxanthine (7-MX), licensed in Denmark since 2009 as a treatment to …

Background: The etiology and the mechanism behind atropine treatment of progressive
myopia are still poorly understood. Our study addressed the role of scleral and choroidal …

Methylxanthine (7-MX, CAS No. 552-62-5, purity 99.46%) is the first orally administered drug
candidate, which showed anti-myopic activity in different pre-clinical studies. In the present …

Myopia is becoming increasingly common. By 2050 around 10% of the world's population is
expected to be highly myopic (<-5 diopters) and therefore particularly at risk of suffering from …

Introduction: Atropine, a muscarinic antagonist, is known since the 19th century to inhibit
myopia development in children. One of its effects is that it stimulates choroidal thickening …