The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …

Public health authorities have described, with growing alarm, an unprecedented increase in
morbidity and mortality associated with use of opioid pain relievers (OPRs). Efforts to …

Background Chronic pain is common and can be challenging to manage. Despite increased
utilisation of opioids, the safety and efficacy of long‐term use of these compounds for chronic …

What is known and objective Opioid use in the United States has reached unprecedented—
some would even say crisis—levels. Although many individuals use opioid drugs as part of …

Most patients with advanced solid cancers exhibit features of cachexia, a debilitating
syndrome characterized by progressive loss of skeletal muscle mass and strength. Because …

Infertility is a widespread problem and a male contribution is involved in 20–70% of affected
couples. As a man's fertility relies on the quantity and quality of his sperm, semen analysis is …

Objective To provide a narrative review of the latest concepts and understanding of the
pathophysiology of critical illness-related corticosteroid insufficiency (CIRCI). Participants A …

Objective: Review, synthesize, and summarize recent evidence on adverse effects of long-
term opioid treatment for noncancer pain and present an organ system-based guide for …

Laboratory Animal Anaesthesia, Fourth Edition provides a basic guide to anaesthesia for a
very diverse audience needing content, with straight-forward, structured style of writing …

In recent decades, the decline in human fertility has become increasingly more worrying:
while therapeutic interventions might help, they are vexing for the couple and often …