Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineages
of blood and immune cells. The maintenance of blood homeostasis requires a dynamic …

Acute myeloid leukemia (AML) is a genetically heterogeneous clonal malignancy
characterized by recurrent gene mutations. Genomic heterogeneity, patients' individual …

Mutational loss of CDKN2A (encoding p16INK4A) tumor-suppressor function is a key
genetic step that complements activation of KRAS in promoting the development and …

Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of
alterations in transcription factors, epigenetic regulators and signaling molecules. To …

The immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide are highly effective
treatments for multiple myeloma. However, virtually all patients eventually relapse due to …

Oxidative stress, caused by the imbalance between reactive species generation and the
dysfunctional capacity of antioxidant defenses, is one of the characteristic features of cancer …

Abstract Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate
growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks …

Abstract The chromosomal translocation t (8; 21) and the resulting oncofusion gene
AML1/ETO have long served as a prototypical genetic lesion to model and understand …

Fusion proteins involving Nucleoporin 98 (NUP98) are recurrently found in acute myeloid
leukemia (AML) and are associated with poor prognosis. Lack of mechanistic insight into …

Chemotherapy-resistant acute myeloid leukemia (AML), frequently driven by clonal
evolution, has a dismal prognosis. A genome-wide CRISPR knockout screen investigating …