Metabolism and regulation of canonical histone mRNAs: life without a poly (A) tail
The canonical histone proteins are encoded by replication-dependent genes and must
rapidly reach high levels of expression during S phase. In metazoans the genes that encode …
rapidly reach high levels of expression during S phase. In metazoans the genes that encode …
mRNA stability in mammalian cells
J Ross - Microbiological reviews, 1995 - Am Soc Microbiol
This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay
rates influence gene expression. mRNA stability influences gene expression in virtually all …
rates influence gene expression. mRNA stability influences gene expression in virtually all …
Delivery of exogenous DNA sequences in a mammal
PL Felgner, JA Wolff, GH Rhodes, RW Malone… - US Patent …, 1996 - Google Patents
Polynucleotide sequences, comprising DNA and RNA mol ecules can be directly
administered, for example by injec tion, to tissues, Such as muscle, and expressed as a …
administered, for example by injec tion, to tissues, Such as muscle, and expressed as a …
Birth and death of histone mRNAs
WF Marzluff, KP Koreski - Trends in Genetics, 2017 - cell.com
In metazoans, histone mRNAs are not polyadenylated but end in a conserved stem-loop.
Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in …
Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in …
The human and mouse replication-dependent histone genes
WF Marzluff, P Gongidi, KR Woods, J Jin, LJ Maltais - Genomics, 2002 - Elsevier
The multigene family encoding the five classes of replication-dependent histones has been
identified from the human and mouse genome sequence. The large cluster of histone genes …
identified from the human and mouse genome sequence. The large cluster of histone genes …
Mechanism and regulation of eukaryotic protein synthesis
WC Merrick - Microbiological reviews, 1992 - Am Soc Microbiol
This review presents a description of the numerous eukaryotic protein synthesis factors and
their apparent sequential utilization in the processes of initiation, elongation, and …
their apparent sequential utilization in the processes of initiation, elongation, and …
Prostaglandin endoperoxide synthase: regulation of enzyme expression
DL DeWitt - Biochimica et Biophysica Acta (BBA)-Lipids and Lipid …, 1991 - Elsevier
Prostaglandin synthesis is initiated when agonists such as histamine [1], bradykinin [2-4],
leukotrienes i5, 6i, angiotensin [7], cytokines [8-111, thrombin [41, or gr:~ th factors [12-14] …
leukotrienes i5, 6i, angiotensin [7], cytokines [8-111, thrombin [41, or gr:~ th factors [12-14] …
Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5′ to 3′ and 3′ to 5′
TE Mullen, WF Marzluff - Genes & development, 2008 - genesdev.cshlp.org
Histone mRNAs are rapidly degraded at the end of S phase or when DNA replication is
inhibited. Histone mRNAs end in a conserved stem–loop rather than a poly (A) tail …
inhibited. Histone mRNAs end in a conserved stem–loop rather than a poly (A) tail …
The poly (A)-poly (A)-binding protein complex is a major determinant of mRNA stability in vitro
P Bernstein, SW Peltz, J Ross - Molecular and cellular biology, 1989 - Taylor & Francis
Using an in vitro mRNA decay system, we investigated how poly (A) and its associated poly
(A)-binding protein (PABP) affect mRNA stability. Cell extracts used in the decay reactions …
(A)-binding protein (PABP) affect mRNA stability. Cell extracts used in the decay reactions …
Identification and Comparison of Stable and Unstable mRNAs in Saccharomyces cerevisiae
D Herrick, R Parker, A Jacobson - Molecular and cellular biology, 1990 - Taylor & Francis
We developed a procedure to measure mRNA decay rates in the yeast Saccharomyces
cerevisiae and applied it to the determination of half-lives for 20 mRNAs encoded by well …
cerevisiae and applied it to the determination of half-lives for 20 mRNAs encoded by well …