Long noncoding RNAs in cancer metastasis

SJ Liu, HX Dang, DA Lim, FY Feng… - Nature Reviews Cancer, 2021 - nature.com
Metastasis is a major contributor to cancer-associated deaths. It is characterized by a
multistep process that occurs through the acquisition of molecular and phenotypic changes …

TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis

Y Hao, D Baker, P Ten Dijke - International journal of molecular sciences, 2019 - mdpi.com
Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …

Tumor immune microenvironment lncRNAs

EG Park, SJ Pyo, Y Cui, SH Yoon… - Briefings in …, 2022 - academic.oup.com
Long non-coding ribonucleic acids (RNAs)(lncRNAs) are key players in tumorigenesis and
immune responses. The nature of their cell type-specific gene expression and other …

[HTML][HTML] Long non-coding RNAs: from disease code to drug role

Y Chen, Z Li, X Chen, S Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively
participate in crucial physiological processes such as metabolism and immunity, and are …

Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy

M Hashemi, MS Moosavi, HM Abed, M Dehghani… - Pharmacological …, 2022 - Elsevier
Initiation and development of cancer depend on multiple factors that mutations in genes and
epigenetic level can be considered as important drivers. Epigenetic factors include a large …

Non-coding RNAs and potential therapeutic targeting in cancer

S Toden, TJ Zumwalt, A Goel - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

Aberrant NSUN2-mediated m5C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma

Z Sun, S Xue, M Zhang, H Xu, X Hu, S Chen, Y Liu… - Oncogene, 2020 - nature.com
RNA methylation is an important epigenetic modification. Recent studies on RNA
methylation mainly focus on the m6A modification of mRNA, but very little is known about the …

E-cadherin: Its dysregulation in carcinogenesis and clinical implications

SHM Wong, CM Fang, LH Chuah, CO Leong… - Critical reviews in …, 2018 - Elsevier
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity

MA Knowles, CD Hurst - Nature reviews cancer, 2015 - nature.com
Urothelial carcinoma of the bladder comprises two long-recognized disease entities with
distinct molecular features and clinical outcome. Low-grade non-muscle-invasive tumours …

Long non-coding RNAs and complex diseases: from experimental results to computational models

X Chen, CC Yan, X Zhang, ZH You - Briefings in bioinformatics, 2017 - academic.oup.com
LncRNAs have attracted lots of attentions from researchers worldwide in recent decades.
With the rapid advances in both experimental technology and computational prediction …