How do lncRNAs regulate transcription?
It has recently become apparent that RNA, itself the product of transcription, is a major
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression
Over the past decade, it has become clear that mammalian genomes encode thousands of
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …
Transcriptional coupling of distant regulatory genes in living embryos
The prevailing view of metazoan gene regulation is that individual genes are independently
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …
RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites
Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to
achieve their diverse functions. To identify these contacts, we developed a method based on …
achieve their diverse functions. To identify these contacts, we developed a method based on …
Long noncoding RNAs: an emerging link between gene regulation and nuclear organization
S Quinodoz, M Guttman - Trends in cell biology, 2014 - cell.com
Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play
important roles in diverse biological processes. As a class, lncRNAs are generally enriched …
important roles in diverse biological processes. As a class, lncRNAs are generally enriched …
UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein–DNA interactions
MA Hume, LA Barrera, SS Gisselbrecht… - Nucleic acids …, 2015 - academic.oup.com
Abstract The Universal PBM Resource for Oligonucleotide Binding Evaluation (UniPROBE)
serves as a convenient source of information on published data generated using universal …
serves as a convenient source of information on published data generated using universal …
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo
MM Gaskill, TJ Gibson, ED Larson, MM Harrison - Elife, 2021 - elifesciences.org
Following fertilization, the genomes of the germ cells are reprogrammed to form the
totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin …
totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin …
Rapid evolutionary turnover underlies conserved lncRNA–genome interactions
Many long noncoding RNAs (lncRNAs) can regulate chromatin states, but the evolutionary
origin and dynamics driving lncRNA–genome interactions are unclear. We adapted an …
origin and dynamics driving lncRNA–genome interactions are unclear. We adapted an …
Modular function of long noncoding RNA, COLDAIR, in the vernalization response
The long noncoding RNA COLDAIR is necessary for the repression of a floral repressor
FLOWERING LOCUS C (FLC) during vernalization in Arabidopsis thaliana. The repression …
FLOWERING LOCUS C (FLC) during vernalization in Arabidopsis thaliana. The repression …
Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification
Little is known about the functional domain architecture of long noncoding RNAs (lncRNAs)
because of a relative paucity of suitable methods to analyze RNA function at a domain level …
because of a relative paucity of suitable methods to analyze RNA function at a domain level …