Emerging themes in CryoEM─ Single particle analysis image processing
Cryo-electron microscopy (CryoEM) has become a vital technique in structural biology. It is
an interdisciplinary field that takes advantage of advances in biochemistry, physics, and …
an interdisciplinary field that takes advantage of advances in biochemistry, physics, and …
Estimating conformational landscapes from Cryo-EM particles by 3D Zernike polynomials
D Herreros, RR Lederman, JM Krieger… - Nature …, 2023 - nature.com
The new developments in Cryo-EM Single Particle Analysis are helping us to understand
how the macromolecular structure and function meet to drive biological processes. By …
how the macromolecular structure and function meet to drive biological processes. By …
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor
AMPA glutamate receptors (AMPARs), the primary mediators of excitatory
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
Computational biophysics meets cryo‐EM revolution in the search for the functional dynamics of biomolecular systems
There is a variety of experimental and computational techniques available to explore protein
dynamics, each presenting advantages and limitations. One promising experimental …
dynamics, each presenting advantages and limitations. One promising experimental …
A robust normalized local filter to estimate compositional heterogeneity directly from cryo-EM maps
Cryo electron microscopy (cryo-EM) is used by biological research to visualize biomolecular
complexes in 3D, but the heterogeneity of cryo-EM reconstructions is not easily estimated …
complexes in 3D, but the heterogeneity of cryo-EM reconstructions is not easily estimated …
ZART: a novel multiresolution reconstruction algorithm with motion-blur correction for single particle analysis
D Herreros, J Kiska, E Ramírez-Aportela… - Journal of Molecular …, 2023 - Elsevier
One of the main purposes of CryoEM Single Particle Analysis is to reconstruct the three-
dimensional structure of a macromolecule thanks to the acquisition of many particle images …
dimensional structure of a macromolecule thanks to the acquisition of many particle images …
[HTML][HTML] Algorithmic robustness to preferred orientations in single particle analysis by CryoEM
The presence of preferred orientations in single particle analysis (SPA) by cryo-Electron
Microscopy (cryoEM) is currently one of the hurdles preventing many structural analyses …
Microscopy (cryoEM) is currently one of the hurdles preventing many structural analyses …
The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities
Cytokines are small proteins that are critical for controlling the growth and activity of
hematopoietic cells by binding to cell surface receptors and transmitting signals across …
hematopoietic cells by binding to cell surface receptors and transmitting signals across …
Amortized template-matching of molecular conformations from cryo-electron microscopy images using simulation-based inference
Biomolecules undergo conformational changes to perform their function. Cryo-electron
microscopy (cryo-EM) can capture snapshots of biomolecules in various conformations …
microscopy (cryo-EM) can capture snapshots of biomolecules in various conformations …
Exploring Advances in Single Particle CryoEM with Apoferritin: from Blobs to True Atomic Resolution
GTR Premageetha, KR Vinothkumar, S Bose - The International Journal of …, 2024 - Elsevier
Deciphering the three-dimensional structures of macromolecules is of paramount
importance for gaining insights into their functions and roles in human health and disease …
importance for gaining insights into their functions and roles in human health and disease …