Highlights•CDK2 has key roles in cell cycle, DNA replication and DNA damage.•Multiple
biomarkers can indicate increased CDK2 activity.•Some cancers have particular …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Mitosis and cytokinesis are undoubtedly the most spectacular parts of the cell cycle. Errors in
the choreography of these processes can lead to aneuploidy or genetic instability, fostering …

Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent
kinases (CDKs) and their activating cyclin subunits. Based on pioneering findings that a …

The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in
other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division,. By contrast …

We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces
centrosome amplification through the simultaneous generation of multiple procentrioles …

Inhibition of the program of apoptosis has been reported to have little or no effect on
clonogenic survival after treatment with drugs or radiation in several tumor cell lines. A …

Many human tumours show centrosome aberrations, indicating an underlying deregulation
of centrosome structure, duplication or segregation. Centrosomes organize microtubule …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

Over a century ago, centrosome aberrations were postulated to cause cancer by promoting
genome instability. The mechanisms governing centrosome assembly and function are …